Acute myeloid leukemia (AML) is an aggressive myeloid malignancy that causes clonal expansion of immature blasts in the blood and bone marrow, leading to ineffective erythropoiesis and bone marrow failure1

  • AML is the most common leukemia type in adults, accounting for 80% of all cases1
  • In 2023, estimates suggest there will be 20,380 new cases of AML and 11,310 deaths from AML in the United States2
  • AML can generally be categorized into de novo AML and secondary AML, which are biologically distinct3
    • Studies suggest that 25% of all AML cases are secondary AML, with 18% to 20% evolving from a myeloid disease and 6% to 8% being therapy related3

Patients with AML tend to experience severe disease burden and have low rates of overall survival1,2,4,5

  • The average patient with AML is around 68 years of age2
    • Despite advancements in treatment options, the prognosis remains very poor in the elderly population1
  • Often patients experience severe physical symptoms, as well as psychological burden, which can significantly impact quality of life4
  • The 5-year relative survival rate for patients with AML is ~32%5

There is an urgent need for further research to advance potential therapies in myeloid malignancies.

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AML, acute myeloid leukemia; CD47, cluster of differentiation 47.

References: 1. Vakiti A, Mewawalla P. Acute Myeloid Leukemia. In: StatPearls [Internet]. StatPearls Publishing; 2023 Jan-. Accessed July 31, 2023. https://www.ncbi.nlm.nih.gov/books/NBK507875/ 2. Key statistics for acute myeloid leukemia (AML). American Cancer Society. Updated January 12, 2023. Accessed July 31, 2023. https://www.cancer.org/cancer/types/acute-myeloid-leukemia/about/key-statistics.html 3. Kuykendall A, Duployez N, Boissel N, et al. Am Soc Clin Oncol Educ Book. 2018;38:555-573. doi:10.1200/EDBK_199519 4. Storey S, Gray TF, Bryant AL. Curr Geriatr Rep. 2017;6(4):247-254. doi:10.1007/s13670-017-0227-8 5. Cancer stat facts: leukemia — acute myeloid leukemia (AML). National Cancer Institute. Accessed July 31, 2023. https://seer.cancer.gov/statfacts/html/amyl.html