A CLOSER LOOK AT MYELOID MALIGNANCIES

Acute myeloid leukemia (AML) is an aggressive myeloid malignancy that causes clonal expansion of immature blasts in the blood and bone marrow, leading to ineffective erythropoiesis and bone marrow failure¹

AML is the most common leukemia type in adults, accounting for 80% of all cases¹
In 2023, estimates suggest there will be 20,380 new cases of AML and 11,310 deaths from AML in the United States²
AML can generally be categorized into de novo AML and secondary AML, which are biologically distinct^{3^{Studies suggest that 25% of all AML cases are secondary AML, with 18% to 20% evolving from a myeloid disease and 6% to 8% being therapy related³}}

Patients with AML tend to experience severe disease burden and have low rates of overall survival^1,2,4,5

The average patient with AML is around 68 years of age²
- Despite advancements in treatment options, the prognosis remains very poor in the elderly population¹
Often patients experience severe physical symptoms, as well as psychological burden, which can significantly impact quality of life⁴
The 5-year relative survival rate for patients with AML is ~32%⁵

There is an urgent need for further research to advance potential therapies in myeloid malignancies.

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AML, acute myeloid leukemia; CD47, cluster of differentiation 47.

References: 1. Vakiti A, Mewawalla P. Acute Myeloid Leukemia. In: StatPearls [Internet]. StatPearls Publishing; 2023 Jan-. Accessed July 31, 2023. https://www.ncbi.nlm.nih.gov/books/NBK507875/ 2. Key statistics for acute myeloid leukemia (AML). American Cancer Society. Updated January 12, 2023. Accessed July 31, 2023. https://www.cancer.org/cancer/types/acute-myeloid-leukemia/about/key-statistics.html 3. Kuykendall A, Duployez N, Boissel N, et al. Am Soc Clin Oncol Educ Book. 2018;38:555-573. doi:10.1200/EDBK_199519 4. Storey S, Gray TF, Bryant AL. Curr Geriatr Rep. 2017;6(4):247-254. doi:10.1007/s13670-017-0227-8 5. Cancer stat facts: leukemia — acute myeloid leukemia (AML). National Cancer Institute. Accessed July 31, 2023. https://seer.cancer.gov/statfacts/html/amyl.html